Medical Research Institute - Project Research CenterDivision of Anticipatory Molecular Food Science and Technology


The Division of Anticipatory Molecular Food Science and Technology aims to elucidate the mechanisms of diabetic complications, in particular, diabetic nephropathy, and to develop a novel therapy for this disease. The main research themes include studies on the mechanisms of diabetes-induced renal fibrosis, the effectiveness of DPP4 inhibitors/endogenous anti-fibrotic peptide AcSDKP, activation of autophagy by caloric restriction or low-protein diet, and the renal protective effect through the maintenance of mitochondrial homeostasis.

Contact Information

TEL: 076-286-2211(3305) / FAX: 076-286-6927 / Email:


Professor and Chair

  • KOYA Daisuke 教授写真

Visiting Professor

  • KANASAKI Keizo

Associate Professor

  • KITADA Munehiro

Research Achievements

Research Activities

  • M.Kitada, Y.Ogura, T.Suzuki, S.Shi, SM.Lee, K.Kanasaki, S.Kume, D.Koya: A very-low-protein diet ameliorates advanced diabetic nephropathy through autophagy induction by suppression of the mTORC1 pathway in Wistar fatty rats, an animal model of type 2 diabetes and obesity, Diabetologia, 59: 1307-1317(6), 2016.
  • K.Nitta, S.Shi, T.Nagai, M.Kanasaki, M.Kitada, SP.Srivastava, M.Haneda, K.Kanasaki, D.Koya: Oral administration of N-acetyl-seryl-aspartyl-lysyl-proline ameliorates kidney disease in both type 1 and type 2 diabetic mice via a therapeutic regimen, Biomed Res Int., 2016: 9172157; 1-11, 2016.
  • S.Shi, S.P.Srivastava, M.Kanasaki, J.He, M.Kitada, T.Nagai, K.Nitta, S.Takagi, K.Kanasaki, D.Koya: Interactions of DPP-4 and integrin β1 influences endothelial-to-mesenchymal transition, Kidney Int., 88: 479-489 (3), 2015.
  • T.Nagai, M.Kanasaki, SP.Srivastava, Y.Nakamura, Y.Ishigaki, M.Kitada, S.Shi, K.Kanasaki, D.Koya: N-acetyl-seryl-aspartyl-lysyl-proline inhibits diabetes-associated kidney fibrosis and endothelial-mesenchymal transition, Biomed Res Int., 2014: 696475; 1-12, 2014.
  • K.Kanasaki, S.Shi, M.Kanasaki, J.He, T.Nagai, Y.Nakamura, Y.Ishigaki, M.Kitada, SP.Srivastava, D.Koya: Linagliptin-mediated DPP-4 inhibition ameliorates kidney fibrosis in streptozotocin-induced diabetic mice by inhibiting endothelial-to-mesenchymal transition in a therapeutic regimen, Diabetes, 63: 2120-2131, 2014.

External Research Funding

  • Grant-in-Aid for Exploratory Research, Daisuke Koya, 2016-2018
  • Grant-in-Aid for Scientific Research(C), Munehiro Kitada, 2017-2019