Medical Research Institute - Project Research CenterDivision of Anticipatory Molecular Food Science and Technology

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The Division of Anticipatory Molecular Food Science and Technology aims to elucidate the mechanisms of diabetic complications, in particular, diabetic nephropathy, and to develop a novel therapy for this disease. The main research themes include studies on the mechanisms of diabetes-induced renal fibrosis, the effectiveness of DPP4 inhibitors/endogenous anti-fibrotic peptide AcSDKP, activation of autophagy by caloric restriction or low-protein diet, and the renal protective effect through the maintenance of mitochondrial homeostasis.

Contact Information

TEL: 076-286-2211(3305) / FAX: 076-286-6927 / Email: endocrin@kanazawa-med.ac.jp

Faculty

Professor and Chair

  • KOYA Daisuke 教授写真

Visiting Professor

  • KANASAKI Keizo

Associate Professor

  • KITADA Munehiro

Research Achievements

Research Activities

  • M.Kitada, Y.Ogura, T.Suzuki, S.Shi, SM.Lee, K.Kanasaki, S.Kume, D.Koya: A very-low-protein diet ameliorates advanced diabetic nephropathy through autophagy induction by suppression of the mTORC1 pathway in Wistar fatty rats, an animal model of type 2 diabetes and obesity, Diabetologia, 59: 1307-1317(6), 2016.
  • K.Nitta, S.Shi, T.Nagai, M.Kanasaki, M.Kitada, SP.Srivastava, M.Haneda, K.Kanasaki, D.Koya: Oral administration of N-acetyl-seryl-aspartyl-lysyl-proline ameliorates kidney disease in both type 1 and type 2 diabetic mice via a therapeutic regimen, Biomed Res Int., 2016: 9172157; 1-11, 2016.
  • S.Shi, S.P.Srivastava, M.Kanasaki, J.He, M.Kitada, T.Nagai, K.Nitta, S.Takagi, K.Kanasaki, D.Koya: Interactions of DPP-4 and integrin β1 influences endothelial-to-mesenchymal transition, Kidney Int., 88: 479-489 (3), 2015.
  • T.Nagai, M.Kanasaki, SP.Srivastava, Y.Nakamura, Y.Ishigaki, M.Kitada, S.Shi, K.Kanasaki, D.Koya: N-acetyl-seryl-aspartyl-lysyl-proline inhibits diabetes-associated kidney fibrosis and endothelial-mesenchymal transition, Biomed Res Int., 2014: 696475; 1-12, 2014.
  • K.Kanasaki, S.Shi, M.Kanasaki, J.He, T.Nagai, Y.Nakamura, Y.Ishigaki, M.Kitada, SP.Srivastava, D.Koya: Linagliptin-mediated DPP-4 inhibition ameliorates kidney fibrosis in streptozotocin-induced diabetic mice by inhibiting endothelial-to-mesenchymal transition in a therapeutic regimen, Diabetes, 63: 2120-2131, 2014.

External Research Funding

  • Grant-in-Aid for Exploratory Research, Daisuke Koya, 2016-2018
  • Grant-in-Aid for Scientific Research(C), Munehiro Kitada, 2017-2019